Domperidone is effective in the prevention of rivastigmine-related gastrointestinal disturbance

Scarzella, Leonardo and Costanza, Alessandra and Vastola, Katia (2007) Domperidone is effective in the prevention of rivastigmine-related gastrointestinal disturbance. Functional Neurology; New Trends in Interventional Neurosciences, 22 (2). pp. 101-104. ISSN 1971-3274

PDF portiere.pdf - Published Version Restricted to Repository staff only Download (33kB)

Abstract

Nausea and/or vomiting are frequent dose-limiting class effects of cholinesterase inhibitors, occurring mostly during the dose-escalation phase. These untoward effects make it difficult to increase rivastigmine dosage above 6 mg daily in most patients. The antiemetic domperidone was given to 22 patients with Alzheimer's disease (9 men, 13 women; mean age 74.5±4.6 years; mean age at diagnosis: 73.1±5.0 years) in 15-day prophylactic cycles, starting 15 days before each dose escalation of rivastigmine above 6 mg daily. Only four patients (18.2%) experienced nausea, which was so mild that all patients reached Ž9 mg rivastigmine daily and 16 (72.7%) reached and maintained the top dosage (12 mg daily). An improvement or stabilization of Mini Mental State Examination scores was achieved in 54.5% of the patients. The treatment regimen was well tolerated; no patients stopped treatment because of adverse events. Further investigations assessing the role of domperidone in the prevention of rivastigmine-related gastrointestinal disturbances are warranted

Item Type:	Article
Uncontrolled Keywords:	Alzheimer’s disease, domperidone, nausea, prevention, rivastigmine
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User:	Danilo Dezzi
Date Deposited:	16 Feb 2012 15:19
Last Modified:	16 Feb 2012 15:19
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3720

Actions (login required)

View Item