Degenerative disease in rotator cuff tears: what are the biochemical and histological changes?

De Giorgi, Silvana and Saracino, Michele and Castagna, Alessandro (2013) Degenerative disease in rotator cuff tears: what are the biochemical and histological changes? Joints, 2 (1). pp. 26-28. ISSN 2282-4324

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Abstract

The histopathological changes associated with rotator cuff tears include thinning and disorganization of collagen fibers, the presence of granulation tissue, increased levels of glycosaminoglycans, fibrocartilaginous metaplasia, calcification, fatty infiltration, and necrosis of the tendon margin with cell apoptosis. The biochemical changes include an increase in the expression of matrix metalloproteinases (MMPs) and a decrease in tissue inhibitor of metalloproteinases (TIMP) messenger ribonucleic acid expression. Histological evidence of tendinopathy has been found in patients with rotator cuff tear. Biochemical changes include significant increases in MMP1, MMP2, MMP3, and in TIMP1 and TIMP2 levels, not only at the lateral supraspinatus edge, but also in the macroscopically intact portion of the supraspinatus tendon and in the intact subscapularis. The tissue in the ruptured area of the supraspinatus tendon undergoes marked rearrangement at molecular levels. This involves the activity of MMP1, 2, and 3 and supports a critical role of MMPs in tendon physiology. Intact parts of the torn supraspinatus tendon can present the histopathological changes associated with rotator cuff tears. These findings suggest that biochemical changes can already occur in a macroscopically intact tendon and seem to point to a global degenerative process in the shoulder.

Item Type:	Article
Uncontrolled Keywords:	Biology, histology, degenerative changes, rotator cuff tear
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia > 617.5 Medicina regionale; Chirurgia regionale
Depositing User:	Chiara D'Arpa
Date Deposited:	10 Nov 2014 11:34
Last Modified:	10 Nov 2014 11:34
URI:	http://eprints.bice.rm.cnr.it/id/eprint/10070

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