Mitohormesis in muscle cells: a morphological, molecular, and proteomic approach

Barbieri, Elena and Sestili, Piero and Vallorani, Luciana and Guescini, Michele and Calcabrini, Cinzia and Gioacchini, Anna Maria and Annibalini, Giosuè and Lucertini, Francesco and Piccoli, Giovanni and Stocchi, Vilberto (2013) Mitohormesis in muscle cells: a morphological, molecular, and proteomic approach. M.L.T.J. Muscles, Ligaments and Tendons Journal, 3 (4). pp. 254-266. ISSN 2240-4554

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Abstract

Low-level oxidative stress induces an adaptive response commonly defined as hormesis; this type of stress is often related to reactive oxygen species (ROS) originating from the mitochondrial respiratory chain (mitochondrial hormesis or mitohormesis). The accumulation of transient low doses of ROS either through chronic physical activity or caloric restriction influences signaling from the mitochondrial compartment to the cell, reduces glucose metabolism, induces mitochondrial metabolism, increases stress resistance and ultimately, increases lifespan. Mitochondrial formation of presumably harmful levels (chronic and/or excessive) of ROS within skeletal muscle has been observed in insulin resistance of obese subjects, type 2 diabetes mellitus, as well as in impaired muscle function associated with normal aging. Advances in mitochondrial bioimaging combined with mitochondrial biochemistry and proteome research have broadened our knowledge of specific cellular signaling and other related functions of the mitochondrial behavior. In this review, we describe mitochondrial remodeling in response to different degrees of oxidative insults induced in vitro in myocytes and in vivo in skeletal muscle, focusing on the potential application of a combined morphological and biochemical approach. The use of such technologies could yield benefits for our overall understanding of physiology for biotechnological research related to drug design, physical activity prescription and significant lifestyle changes

Item Type:	Article
Uncontrolled Keywords:	Mitochondria, skeletal muscle, ROS, hormesis
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	14 Nov 2014 16:48
Last Modified:	12 Dec 2014 12:11
URI:	http://eprints.bice.rm.cnr.it/id/eprint/10090

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