Giorlandino, Claudio and Brizzi, Cristiana and Giorlandino, Maurizio and Taramanni, Cinzia and Mastrandrea, Maria Luisa and Coco, Claudio and Mangiafico, Lucia and Cignini, Pietro and D’Emidio, Laura and Raffio, Raffaella and Padula, Francesco and Sebastianelli, Antonella and Nanni, Cinzia and Carcioppolo, Ornella and Lena, Alessandro and Giorgio, Elsa and Dugo, Nella and Milite, Vincenzo and Lippa, Assunta and Vigna, Roberto and Giannarelli, Diana and Mobili, Luisa (2013) Effect of vaginally administered DHAfatty acids on pregnancy outcome in high risk pregnancies for preterm delivery: a double blinded randomised controlled trial. Journal of prenatal medicine, 7 (3). pp. 42-45. ISSN 1971-3290
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Abstract
Objectives: to verify whether vaginally intake of docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid, would improve length of gestation and newborn birth weight in high risk pregnancies for preterm delivery. Methods: this study was a randomized, double-blind, controlled, clinical trial, including women at high risk for preterm delivery. Of 74 eligible women, 31 refused to participate and 34 were enrolled and randomized with equal chance of selection, 22 were assigned to treatment Group and 21 were assigned to the control group, and received placebo. One gram of DHA was administered vaginally once a day starting from 21 (1 week of gestation until 37 weeks + 0 day). The primary endpoint was to determine the length of the pregnancy and secondary endpoint the newborn weight. Results: gestational age at delivery was 38.6 (SD, 1.05) weeks in the docosahexaenoic acid group and 37.6 (SD, 0.84) weeks in the placebo group (P =0.007). For women who completed the treatment and delivered at term there was a statistically difference of the weights in the two groups [3082.1 (SD, 293) gr cases vs 2699.3 (SD, 150) gr controls P <0.0001]. Conclusion: in high risk patients for preterm delivery, the vaginal administration of a DHA increases length of gestation and newborn birth weight.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | vaginal DHA, omega-3, preterm delivery, high risk pregnancy, docosahexaenoic acid |
| Subjects: | 500 Scienze naturali e Matematica > 570 Scienze della vita; Biologia |
| Depositing User: | Marina Spanti |
| Date Deposited: | 25 Jan 2016 17:06 |
| Last Modified: | 25 Jan 2016 17:06 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/10335 |
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