Jevnikar, Mitja and Torregiani, Chiara (2014) Chronic inflammation and frequent exacerbations in patients with COPD: the role of PDE4 inhibitors. Shortness of Breath, 3 (2). pp. 84-90. ISSN 2281-6550
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Abstract
Inflammation represents an important hallmark of several diseases. In COPD the inflammatory lung response may be chronic and dysregulated with accumulation of inflammatory cells that causes lung parenchyma damage and airway remodeling. The inflammatory cascade involves different cells, mediators, proteins, oxygen species that leads the local inflammation to become systemic and promotes comorbidities and complications. Different stimuli may worsen the COPD pathology, including the well known COPD exacerbation, a peak of local and systemic inflammation. Also hypoxia may stimulate inflammatory genes worsening local and systemic level of inflammation. Understanding the inflammation can allow us to differentiate COPD phenotype and lead as to personalize the therapy. Several have the specific target of inflammation, particularly PDE4 inhibitors may have a role in certain COPD phenotype.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | chronic obstructive pulmonary disease, COPD, inflammation, phosphodiesterase-4, roflumilast, acute exacerbation |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 21 Jan 2016 17:49 |
| Last Modified: | 21 Jan 2016 17:49 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/10512 |
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