CMV management in lung transplant recipients

Solidoro, Paolo and Costa, Cristina and Libertucci, Daniela and Delsedime, Luisa and Boffini, Massimo and Ricci, Davide and Bucca, Caterina and Cavallo, Rossana and Rinaldi, Mauro (2014) CMV management in lung transplant recipients. Shortness of Breath, 3 (3). pp. 114-125. ISSN 2281-6550

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Human cytomegalovirus (HCMV) is a member of the Betaherpesvirinae subfamily (Herpesviridae family), that, following primary infection, is able to establish latency in host tissues and may reactivate in conditions of immunosuppression. In solid organ transplant recipients, the incidence of CMV infection and disease varies according to the transplanted organ and is particularly high in lung transplantation (LT), reaching 40-50% incidence. Lung is a CMV latency site and in LT, viral reactivation has been associated with direct (i.e. organ and systemic infection/disease) and indirect effects (including acute rejection and chronic allograft dysfunction). The clinical importance of CMV has grown in parallel with the increasing number of solid organ transplant recipients. Symptoms related to CMV disease and the prevention of CMV infection show variation among different patient populations, depending on the type of transplant and the intensity of immunosuppression. Treatment and prevention of CMV infection have assumed increasing importance in lung transplant recipients management relative to the mortality and morbidity and, on the other hand, to the availability of effective antiviral agents as well as new diagnostic techniques and the prophylaxis, diagnosis, and treatment of CMV infections. In lung transplant recipients management is evolving with experience and we are living the sunrise of a new personalized or tailored management era matching, almost in real time, infection, diagnosis, immunity status and therapy.

Item Type: Article
Uncontrolled Keywords: CMV infection, lung transplant, acute rejection, chronic rejection, hyperimmune globulins
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
Depositing User: Marina Spanti
Date Deposited: 21 Jan 2016 17:39
Last Modified: 21 Jan 2016 17:39

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