Abbruzzese, Giovanni and Barone, Paolo and Bonuccelli, Ubaldo and Lopiano, Leonardo and Antonini, Angelo (2012) Continuous intestinal infusion of levodopa/carbidopa in advanced Parkinson’s disease: efficacy, safety and patient selection. Functional Neurology, 27 (3). pp. 147-154. ISSN 1971-3274
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Abstract
Long-term oral therapy with levodopa is associated with the development of motor fluctuations and dyskinesia in a large percentage of patients with Parkinson’s disease (PD). Motor complications are associated with a number of non-motor symptoms and have a negative impact on disability and quality of life. There are three therapeutic options available for the management of patients at this advanced stage: high frequency deep brain stimulation, continuous subcutaneous infusion of apomorphine, and continuous intestinal infusion of levodopa/carbidopa. On the basis of published data and in consideration of the risk-benefit profile of current therapeutic strategies, we here propose an algorithm to help clinicians select the most suitable treatment option for patients with advanced PD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | continuous dopaminergic stimulation, deep brain stimulation, levodopa/carbidopa intestinal gel infusion, Parkinson’s disease, patient selection |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 08 Jan 2016 12:38 |
| Last Modified: | 08 Jan 2016 12:38 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/10688 |
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