Mori, Francesco and Kusayanagi, Hajime and Buttari, Fabio and Centini, Barbara and Monteleone, Fabrizia and Gabri Nicoletti, Carolina and Bernardi, Giorgio and Verdun Di Cantogno, Elisabetta and Marciani, Maria Grazia and Centonze, Diego (2012) Early treatment with high-dose interferon beta-1a reverses cognitive and cortical plasticity deficits in multiple sclerosis. Functional Neurology, 27 (3). pp. 163-168. ISSN 1971-3274
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Abstract
Acute inflammation is associated with cognitive deficits and alterations of cortical plasticity in multiple sclerosis (MS). We tested whether early treatment with high-dose interferon (IFN) beta-1a, known to reduce inflammatory activity, improves cortical function and cognitive deficits in MS. Eighty treatment-naïve relapsing-remitting MS (RRMS) patients received IFN beta-1a (44 mcg) subcutaneously three times per week. Cognitive performance and cortical plasticity were measured through the paced auditory serial addition test (PASAT) and intermittent theta burst stimulation (iTBS) before and up to two years after IFN beta-1a initiation. Before treatment, patients with gadolinium-enhancing lesions (Gd+) on MRI performed worse on the PASAT, and showed lower iTBS-induced plasticity, compared with Gd- patients. Six months after treatment initiation both PASAT and iTBS-induced plasticity improved in Gd+ and remained stable in Gd- patients. These results suggest that cognitive and synaptic plasticity deficits may be rescued during high-dose IFN beta-1a treatment in newly-diagnosed RRMS patients with Gd+ lesions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cognition, inflammation, PASAT, synaptic plasticity, theta burst stimulation, transcranial magnetic stimulation |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 08 Jan 2016 12:36 |
| Last Modified: | 08 Jan 2016 12:36 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/10691 |
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