Neurogenic neuroprotection: clinical perspectives

Mandel, Mauricio and Talamoni Fonoff, Erich and Bor-Seng-Shu, Edson and Jacobsen Teixeira, Manoel and Chadi, Gerson (2012) Neurogenic neuroprotection: clinical perspectives. Functional Neurology, 27 (4). pp. 207-216. ISSN 1971-3274

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Neurogenic neuroprotection is a promising approach for treating patients with ischemic brain lesions. In rats, stimulation of the deep brain nuclei has been shown to reduce the volume of focal infarction. In this context, protection of neural tissue can be a rapid intervention that has a relatively long-lasting effect, making fastigial nucleus stimulation (FNS) a potentially valuable method for clinical application. Although the mechanisms of neuroprotection induced by FNS remain partially unclear, important data have been presented in the last two decades. A 1-h electrical FNS reduced, by 59%, infarctions triggered by permanent occlusion of the middle cerebral artery in Fisher rats. The acute effect of electrical FNS is likely mediated by a prolonged opening of potassium channels, and the sustained effect appears to be linked to inhibition of the apoptotic cascade. A better understanding of the neuronal circuitry underlying neurogenic neuroprotection may contribute to improving neurological outcomes in ischemic brain insults.

Item Type: Article
Uncontrolled Keywords: cerebrovascular accident, fastigial nucleus, neurogenic neuroprotection stroke, subarachnoid hemorrhage
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
Depositing User: Marina Spanti
Date Deposited: 08 Jan 2016 12:15
Last Modified: 08 Jan 2016 12:15

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