Sleep in ring chromosome 20 syndrome: a peculiar electroencephalographic pattern

Zambrelli, Elena and Vignoli, Aglaia and Nobili, Lino and Didato, Giuseppe and Mastrangelo, Massimo and Turner, Katherine and Canevini, Maria Paola (2013) Sleep in ring chromosome 20 syndrome: a peculiar electroencephalographic pattern. Functional Neurology, 28 (1). pp. 47-53. ISSN 1971-3274

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Ring chromosome 20 [r(20)] syndrome is a chromoso- mal disorder characterized by epilepsy and intellectual disability. Distinctive electroclinical features and wake- fulness EEG patterns have been described. The EEG features of sleep have not yet been evaluated. We studied the pattern of sleep in six patients aged 2-59 years who underwent at least one polysomno- graphic recording. Their sleep pattern evolution is described as deteriora- tion ranging from normal to destructured NREM/REM sleep. NREM sleep alterations were observed from childhood and were more evident in adulthood. EEG abnormalities detected during wakefulness persisted, with morphological changes, during sleep. During NREM sleep all the subjects presented high amplitude delta sequences with a sharply contoured or notched appearance, prevalent over frontal regions. The theta rhythm of wakefulness was seen to persist during REM sleep. Ring chromosome 20 syndrome shows sleep alter- ations that seem to be age-related. A potential role of cortical and thalamocortical dysfunction is discussed. KEY WORDS:

Item Type: Article
Uncontrolled Keywords: electroencephalography, epilepsy, ring chromosome 20 syndrome, sleep
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
Depositing User: Marina Spanti
Date Deposited: 17 Dec 2015 16:16
Last Modified: 17 Dec 2015 16:16

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