Dallaudiere, Benjamin and Zurlinden, Olivier and Perozziello, Anne and Deschamps, Lydia and Larbi, Ahmed and Louedec, Liliane and Pesquer, Lionel and Benayoun, Yohan and Silvestre, Alain and Serfaty, Jean Michel (2014) Combined intra-tendinous injection of Platelet Rich Plasma and bevacizumab accelerates and improves healing compared to Platelet Rich Plasma in tendinosis: comprehensive assessment on a rat model. M.L.T.J. Muscles, Ligaments and Tendons Journal, 4 (3). pp. 351-356. ISSN 2240-4554
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Abstract
Purpose: the aim of our study was to assess the potential of combined intratendinous injection of an anti-angiogenic drug: bevacizumab (AA) and Platelet Rich Plasma (PRP) to treat tendinopathy in a murine model of patellar and Achilles tendinopathy, and to evaluate its local toxicity. Material and method: twenty rats (80 patellar and Achilles tendons) were used for the study. We induced tendinosis (T+) in 80 tendons (patellar=40 and Achilles=40) by injecting under ultrasonography (US) guidance Collagenase 1® (day 0 = D0). Clinical examination was performed at D3, immediately followed by either PRP and AA (AAPRPT+, n=40) or PRP (PRPT+ n=40, control) US-guided intratendinous injection. Follow-up at D6, D18 and D25 using clinical, US and histology, and comparison between the 2 groups were performed. To study AA+PRP toxicity, we looked for necrosis or rupture on the 40 AAPRPT+. Results: all AAPRPT+ showed better joint mobilization compared to PRPT+ at D6 (p=0.03), D18 (p=0.04) and D25 (p=0.02). Similar results were found regarding US and histology, with smaller collagen fiber diameters (D6, p≤0.017, D25, p≤0.015), less disorganization and fewer neovessels (D25, p=0.004) in AAPRPT+ compared to PRPT+. No AA+PRP local toxicity was discovered in histology assessment. Conclusion: our study suggests that combined injection of AA and PRP in tendinosis accelerates and improves tendon’s healing compared PRP used alone, with no local toxicity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | anti-angiogenic, PRP, rat, tendon, tendinosis, US |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia > 617.1 Ferite e lesioni |
| Depositing User: | Chiara D'Arpa |
| Date Deposited: | 03 Jun 2015 10:17 |
| Last Modified: | 03 Jun 2015 10:17 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/11223 |
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