Pulmonary fibrosis and lung cancer: not the same disease, but not so different

Torrisi, Sebastiano Emanuele and Puglisi, Silvia and Vindigni, Virginia and Giuliano, Riccardo and Palmucci, Stefano and Vancheri, Carlo (2015) Pulmonary fibrosis and lung cancer: not the same disease, but not so different. Shortness of breath, 4 (1). pp. 3-9. ISSN 2281-6550

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Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia characterized by a poor survival, even worse than many cancers. Recent studies have demonstrated that IPF and cancer share several cellular and molecular alterations related to epigenetic and genetic changes, altered regulation of apoptosis, abnormal response to regulatory signals, abnormal expression of microRNAs (mRNAs), reduced cell-to-cell communication and activation of specific signaling pathways. This leads to the hypothesis that IPF can be considered, in some respects, a cancer-like disease. This correlation may help in understanding the pathogenesis of IPF by exploiting the great knowledge of the biological mechanisms studied in cancer but it may also help in increasing the awareness of this disease at public, political and even at healthcare level. In addition, the identification of common pathogenic pathways between the two diseases may stimulate new clinical trials with cancer drugs, as in the case of nintedanib, and drugs combinations or different lines of drugs as largely experimented in cancer.

Item Type: Article
Uncontrolled Keywords: interstitial lung diseases, idiopathic pulmonary fibrosis, cancer, epigenetic alterations, cell to cell communications, signal transduction pathways, myofibroblasts, TGF-β, tyrosine kinases
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
Depositing User: Marina Spanti
Date Deposited: 19 Sep 2019 13:21
Last Modified: 19 Sep 2019 13:21
URI: http://eprints.bice.rm.cnr.it/id/eprint/12434

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