Treatments of post-surgical fistulas with particular emphasys to stem cells therapy

Petrella, Francesco and Spaggiari, Lorenzo (2015) Treatments of post-surgical fistulas with particular emphasys to stem cells therapy. Shortness of breath, 4 (2). pp. 42-46. ISSN 2281-6550

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Post resectional bronchopleural fistula is a pathological connection between the airway and the pleural space that may develop after surgical lung resection. It is still the most feared complication about after curative lung resection because current treatments are often far to be satisfactory. For this reason great attention has been reached about the healing effects promoted by stem cells through transformation into mature cells with a specialized function or by enhancing intrinsic repair mechanisms. This may represent an effective therapeutic option, as showed by our team, only partially explored to date. Nevertheless, there is still a lack of consensus regarding the optimal management of a fistula, but an individualized approach is recommended. Several strategies have been suggested to manage this problematic condition with a variable success rate: invasive surgery, direct closure with re-enforcement of the pleura, or using flaps from pericardium, intercostal tissue or omentus. A less invasive option suggested by several Authors is the endoscopic use of fibrin glue or silver nitrate. In conclusion, although cellular therapies are a new interesting therapeutic approach for the closure of airway fistulas, more basic research and clinical experiences are needed to get this promising therapy as a routine tool for treating this insidious post-surgical complication. Currently, a standard surgical and conservative approach still remain the first choice therapeutic option for post-surgical bronchopleural fistulas.

Item Type: Article
Uncontrolled Keywords: Bronchopleural fistula, mesenchimal stem cell, Eloesser flap, Clagget procedure
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
Depositing User: Marina Spanti
Date Deposited: 19 Sep 2019 13:39
Last Modified: 19 Sep 2019 13:39

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