Encephalopathy with status epilepticus during sleep (ESES) induced by oxcarbazepine in idiopathic focal epilepsy in childhood

Pavlidis, Elena and Rubboli, Guido and Nikanorova, Marina and Kölmel, Margarethe Sophie and Gardella, Elena (2015) Encephalopathy with status epilepticus during sleep (ESES) induced by oxcarbazepine in idiopathic focal epilepsy in childhood. Functional Neurology, 30 (2). pp. 139-141. ISSN 1971-3274

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Encephalopathy with status epilepticus during sleep (ESES) is an age-related disorder characterized by neuropsychological regression, epilepsy and a typical EEG pattern of continuous epileptiform activity (> 85%) during NREM sleep. Cases of worsening or induction of ESES with phenytoin, carbamazepine and phenobarbital have been reported. We describe a child with benign epilepsy with centrotemporal spikes (BECTS) in whom treatment with oxcarbazepine (OXC) induced ESES. The patient was studied through repeated clinical-neuropsychological evaluations and 24-hour EEG recordings. He was treated with OXC two months after epilepsy onset. One month after starting OXC, he developed an abrupt and severe cognitive deterioration. A 24-hour EEG and neuropsychological tests showed an electro-clinical picture compatible with ESES. Withdrawal of OXC and introduction of other drugs were followed by a prompt improvement. Five months after ESES onset, a 24-hour EEG was normal. Our report indicates that OXC can induce ESES in BECTS.

Item Type: Article
Uncontrolled Keywords: Antiepileptic drugs (AEDs), benign epilepsy of childhood with centrotemporal spikes (BECTS), encephalopathy with status epilepticus during sleep (ESES), idiopathic focal epilepsies of childhood, oxcarbazepine (OXC)
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User: Marina Spanti
Date Deposited: 23 Sep 2019 12:58
Last Modified: 23 Sep 2019 12:58
URI: http://eprints.bice.rm.cnr.it/id/eprint/12584

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