Intravenous methylprednisolone pulse therapy for children with epileptic encephalopathy

Pera, Maria Carmela and Randazzo, Giovanna and Masnada, Silvia and Donetti Dontin, Serena and De Giorgis, Valentina and Balottin, Umberto and Veggiotti, Pierangelo (2015) Intravenous methylprednisolone pulse therapy for children with epileptic encephalopathy. Functional Neurology, 30 (3). pp. 173-179. ISSN 1971-3274

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The aim of this retrospective study of children affected by epileptic encephalopathy was to evaluate seizure frequency, electroencephalographic pattern and neuropsychological status, before and after intravenous methylprednisolone therapy. Eleven children with epileptic encephalopathy were administered one cycle of intravenous methylprednisolone (15–30 mg/kg/day for three consecutive days, once a month for four months) in addition to constant dosages of their regular antiepileptic drugs. The treatment resulted in statistically significant reductions of generalized slow spike-and-wave discharges (p<0.0028) and seizure frequency (p<0.013), which persisted even after methylprednisolone pulse therapy was stopped. A globally positive outcome was noted in 9/11 patients (81.8%). This methylprednisolone treatment regimen did not cause significant or persistent adverse effects. We suggest that children with epileptic encephalopathy without an underlying structural lesion could be the best candidates for intravenous methylprednisolone pulse therapy.

Item Type: Article
Uncontrolled Keywords: Epileptic encephalopathy, intravenous methylprednisolone, refractory epilepsy
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User: Marina Spanti
Date Deposited: 24 Sep 2019 11:38
Last Modified: 24 Sep 2019 11:38

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