de Pasquale, Francesco and Falletta Caravasso, Chiara and Péran, Patrice and Catani, Sheila and Tuovinen, Noora and Sabatini, Umberto and Formisano, Rita (2015) Functional magnetic resonance imaging in disorders of consciousness: preliminary results of an innovative analysis of brain connectivity. Functional Neurology, 30 (3). pp. 193-201. ISSN 1971-3274
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Abstract
The aim of this preliminary study was to present a new approach for connectivity analysis in patients with severe acquired brain injury (ABI) that overcomes some of the difficulties created by anatomical abnormalities due to the brain injury. Using a data-driven approach, resting-state structural MRI (sMRI) and functional MRI (fMRI) data from three severe ABI patients – two with disorders of consciousness (DOC) and one who had recovered consciousness (non-DOC) – were integrated and analyzed. Parameters extracted from the distribution of the connectivity values, such as mean, standard deviation and skeweness, were considered. The distribution parameters estimated seem to provide an accurate multivariate classification of the considered cases that can be summarized as follows: connectivity in the severe ABI patients with DOC was on average lower than in the severe ABI non-DOC patient and healthy subjects. The dispersion of connectivity values of the severe ABI patients, non-DOC and DOC, was comparable, however the shape of the distribution was different in the non-DOC patient. Eventually, seed-based connectivity maps of the default mode network show a pattern of increasing disruption of this network from the healthy subjects to non-DOC and DOC patients. Consistent results are obtained using an ICA-based approach.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Brain connectivity, disorders of consciousness, magnetic resonance imaging, minimally conscious state, vegetative state |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.8047548 Sistema Nervoso – Risonanza magnetica nucleare (Classificare qui: Neuroimaging, Neuroimaging funzionale, Cervello - Risonanza magnetica funzionale, Cervello - Risonanza magnetica per immagini) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 24 Sep 2019 11:45 |
| Last Modified: | 24 Sep 2019 11:45 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/12610 |
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