A review of cognitive impairment and differential diagnosis in idiopathic normal pressure hydrocephalus

Picascia, Marta and Zangaglia, Roberta and Bernini, Sara and Minafra, Brigida and Sinforiani, Elena and Pacchetti, Claudio (2015) A review of cognitive impairment and differential diagnosis in idiopathic normal pressure hydrocephalus. Functional Neurology, 30 (4). pp. 217-229. ISSN 1971-3274

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Idiopathic normal pressure hydrocephalus (iNPH) is a complex and still underestimated pathology. In the early stages, the cognitive profile is characterized mainly by impairments of attention, psychomotor speed and memory, suggesting frontal involvement; patients with more advanced iNPH show overall cognitive deterioration. The memory impairment, however, seems to be milder than that seen in Alzheimer’s disease (AD). Clinical and neuroimaging data are crucial for the diagnosis of iNPH, but the presence of different variables, such as comorbidities, and the possible overlapping with other neurodegenerative diseases, AD in particular, make the differential diagnosis difficult. To date studies seeking to identify possible biological markers have provided inconclusive results; moreover reliable indices predictive of a good response to surgery are still lacking. There is a need for further studies with longer follow-ups and for closer interaction among the different professionals involved.

Item Type: Article
Uncontrolled Keywords: Alzheimer’s disease, biological markers, cognitive impairment, idiopathic normal pressure hydrocephalus, shunt surgery
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.83 Altre malattie organiche del sistema nervoso centrale (Include la corea ed i disturbi coreici ad eccezione della malattia di Huntington (in 616.851) (Classificare qui, in 616.83, le malattie dei gangli vasali, del midollo spinale) > 616.831 Malattia di Alzheimer (Classificare le opere d’insieme sulla demenza in 616.83)
Depositing User: Marina Spanti
Date Deposited: 24 Sep 2019 12:20
Last Modified: 24 Sep 2019 12:20
URI: http://eprints.bice.rm.cnr.it/id/eprint/12613

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