Ma, Zhengwen and Li, Yao and Zhang, Yi Ping and Shields, Lisa B. E. and Xie, Qing and Yan, Guofeng and Liu, Wei and Chen, Guoqiang and Zhang, Ying and Brommer, Benedikt and Xu, Xiao-Ming and Lu, Yi and Chen, Xuejin and Shields, Christopher B. (2015) Thermal nociception using a modified Hargreaves method in primates and humans. Functional Neurology, 30 (4). pp. 229-236. ISSN 1971-3274
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Abstract
Nociception is an important protective mechanism. The Hargreaves method, which involves measuring withdrawal latency following thermal stimulation to Thermal nociception using a modified Hargreaves method in primates and humans the paw, is commonly used to measure pain thresholds in rodents. We modified this technique to measure pain thresholds in monkeys and humans. The modified Hargreaves method was used to quantitate pain sensitivity in eight normal rhesus monkeys, 55 human volunteers, and 12 patients with spinal cord or cauda equina lesions. Thermal stimulation was delivered at 80% of maximum output, and the duration of the stimulation was set at a maximum of 10 seconds to avoid skin injury. The following withdrawal latencies were recorded: 2.7±0.12 seconds in volunteers and 3.4±0.35 seconds in neurologically intact monkeys (p>0.05). Patients with spinal cord or cauda equina lesions showed significantly increased latencies (p<0.001). The modified Hargreaves technique is a safe and reliable method that can provide a validated measure of physiological pain sensation.
| Item Type: | Article |
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| Uncontrolled Keywords: | Hargreaves, monkeys, pain, spinal cord injury, threshold |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 612 Fisiologia umana > 612.8 Funzioni nervose, funzioni sensorie (Classificare qui la Neurofisiologia, la Psicofisiologia) > 612.82 Cervello (classificare qui il sistema nervoso centrale, le Neuroscienze, le Neuroscienze cognitive) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 24 Sep 2019 14:11 |
| Last Modified: | 24 Sep 2019 14:11 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/12614 |
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