Cortical excitability changes over time in progressive multiple sclerosis

Ayache, Samar S. and Créange, Alain and Farhat, Wassim H. and Zouari, Hela G. and Lesage, Catherine and Palm, Ulrich and Abdellaoui, Mohammed and Lefaucheur, Jean-Pascal (2015) Cortical excitability changes over time in progressive multiple sclerosis. Functional Neurology, 30 (4). 257 -263. ISSN 1971-3274

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In 25 patients with progressive forms of multiple sclerosis (MS), motor cortex excitability was longitudinally studied over one year by means of transcranial magnetic stimulation (TMS). The following TMS parameters were considered: resting and active motor thresholds (MTs), input-output curve, short-interval intracortical inhibition (SICI), and intracortical facilitation. Clinical evaluation was based on the Expanded Disability Status Scale (EDSS). In the 16 patients not receiving disease-modifying drugs, the EDSS score worsened, resting MT increased, and SICI decreased. By contrast, no clinical for neurophysiological changes were found over time in the nine patients receiving immunomodulatory therapy. The natural course of progressive MS appears to be associated with a decline in cortical excitability of both pyramidal neurons and inhibitory circuits. This pilot study based on a small sample suggests that disease-modifying drugs may allow cortical excitability to remain stable, even in patients with progressive MS.

Item Type: Article
Uncontrolled Keywords: Cortical excitability, disease course, motor cortex, multiple sclerosis, progressive form, treatment
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User: Marina Spanti
Date Deposited: 24 Sep 2019 14:15
Last Modified: 24 Sep 2019 14:15

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