Dzieżyc, Karolina and Litwin, Tomasz and Chabik, Grzegorz and Członkowska, Anna (2015) Measurement of urinary copper excretion after 48-h d-penicillamine cessation as a compliance assessment in Wilson’s disease. Functional Neurology, 30 (4). pp. 264-268. ISSN 1971-3274
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Abstract
Treatment of Wilson’s disease (WD) with anti-copper agents is effective in most compliant patients. During long-term treatment with chelating agents, a two-day interruption of the treatment should result in normal urinary copper concentrations (<50 μg/dl). The aim of this study was to establish the usefulness of this method as a compliance assessment in these patients. We examined consecutive patients treated with d-penicillamine (DPA) undergoing routine follow-up studies at our center. We performed 24-h urinary copper excretion analysis 48 h after interruption of chelating therapy. Thirty-two patients were enrolled. After DPA cessation, normalization of copper excretion was observed in 91% of reportedly compliant patients. The specificity and sensitivity values of this test were 87% and 77%, respectively. Measurement of 24-h urinary copper excretion after a 48-h interruption of DPA therapy in patients with WD is a reliable method for confirming patients’ compliance.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Compliance assessments, d-penicillamine, urinary copper excretion, Wilson’s disease |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 24 Sep 2019 14:16 |
| Last Modified: | 24 Sep 2019 14:16 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/12665 |
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