Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions

Gabbiani, Chiara (2009) Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions. Premio FUP. Tesi di dottorato, 9 (9). Firenze University Press, Firenze. ISBN 978-88-8453-940-3

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Abstract

There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. Valuable structural and functional information on these adducts could be derived from several biophysical studies mainly relying on the application of X-ray diffraction and ESI MS techniques. The structural and functional information achieved on the respective metallodrug-protein adducts allowed us to identify some general trends in the reactivity of anticancer metallodrugs with protein targets

Item Type:	Book
Subjects:	500 Scienze naturali e Matematica > 570 Scienze della vita; Biologia 500 Scienze naturali e Matematica > 540 Chimica e scienze connesse 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User:	FUP firenze university press
Date Deposited:	02 Mar 2010
Last Modified:	20 May 2010 12:03
URI:	http://eprints.bice.rm.cnr.it/id/eprint/1313

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