Adjuvant Effect of Leuprolide on Stroke: A Case report

Tadeo, Carlo Sebastiano and Incorvaia, Barbara and Russo, Raffaela and De Lauretis, Luciana (2014) Adjuvant Effect of Leuprolide on Stroke: A Case report. European Journal of Case Reports in Internal Medicine, 1 (1). pp. 1-3. ISSN 2284-2594

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Objectives: To contribute to current knowledge on the vascular risk of oestrogens. Materials and methods: A 44-year-old woman received a 11.25 mg Leuprolide exteneded release injection to control bleeding from a 7 cm uterine fibroid tumour; 45 days later, she had a stroke due to right frontal lobe ischaemia. Thrombolysis induced complete remission. Three years previously, while taking a birth control pill, the patient had suffered from a stroke that involved her left temporal lobe. She was heterozygous for Factor V R2 H1299R locus and homozygous for the 4G/4G mutation of the PAI-1 gene. Even though her homocysteine level was normal, the patient was homozygous for the MTHFR C677T mutation and although she had never had severe bleeding, she was also homozygous for Factor XIII V34L. Results and conclusion: This patient’s prothrombotic condition could have been enhanced by leuprolide since its stimulatory effect on oestrogen production would still have been minimally present at the time of cerebral thrombosis.

Item Type: Article
Uncontrolled Keywords: Leuprolide, stroke, thrombosis, thrombolysis, coagulation abnormalities, LHRH analogues
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.1 Malattie del sistema cardiovascolare
Depositing User: Chiara D'Arpa
Date Deposited: 02 Aug 2016 16:17
Last Modified: 03 Aug 2016 08:18

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