Long Term Therapy with Lenalidomide in a patient with POEMS Syndrome

Chu, Benjamin and Shana'ah, Arwa and Hofmeister, Craig C. and Benson, Don M. and Sella, Megan and Tucker, Jill and Pichiorri, Flavia and Efebera, Yvonne A. (2014) Long Term Therapy with Lenalidomide in a patient with POEMS Syndrome. European Journal of Case Reports in Internal Medicine, 1 (1). pp. 1-4. ISSN 2284-2594

93-1120-5-PB.pdf - Published Version

Download (313kB) | Preview
Official URL: http://ejcrim.com/index.php/EJCRIM/article/view/93


Lenalidomide is an effective therapy against malignant plasma cells and a potent agent against proinflammatory and proangiogenic cytokines. The use of lenalidomide in POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein with plasma cells, skin changes) has been reported, but its benefit in long-term use is not well established. A 55-year-old man with POEMS and debilitating polyneuropathy was treated with lenalidomide and dexamethasone followed by maintenance lenalidomide. He remains in haematologic remission and in complete recovery of functional status 3.5 years after diagnosis. This case supports the long-term use of lenalidomide in patients with POEMS syndrome.

Item Type: Article
Uncontrolled Keywords: lenalidomide, POEMS
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 04 Aug 2016 16:12
Last Modified: 04 Aug 2016 16:12
URI: http://eprints.bice.rm.cnr.it/id/eprint/14929

Actions (login required)

View Item View Item