Leishmaniasis Mimicking Lymphoma and/or Liver Cirrhosis

Rossi, Luca and Leutner, Monica and Sola, Daniele and Bartoli, Ettore (2014) Leishmaniasis Mimicking Lymphoma and/or Liver Cirrhosis. European Journal of Case Reports in Internal Medicine, 1 (1). pp. 1-7. ISSN 2284-2594

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A 76-year-old man was admitted to hospital with fever, weight loss, pancytopenia, hepatosplenomegaly and a double monoclonal component IgM-IgG-k, suggesting a diagnosis of myeloma. Bone marrow and liver biopsies disclosed the presence of Donovan bodies, and the titre of anti-Leishmania antibodies was extremely high. After treatment with liposomal amphotericin B, the titre of antibodies fell considerably, while monoclonal components, pancytopenia and clinical symptoms slowly disappeared. Polyclonal γ-globulins are made of innumerable monoclonal components, one of which can appear as a recognizable band and be misdiagnosed as myeloma when representing the high titre of an antibody directed towards a specific antigen.

Item Type: Article
Uncontrolled Keywords: Leishmaniasis, multiple myeloma, lymphoma, liver cirrhosis, M-components
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 07 Sep 2016 15:39
Last Modified: 07 Sep 2016 15:39
URI: http://eprints.bice.rm.cnr.it/id/eprint/14965

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