Seizure and Profound Hypokalemia: Unusual Presentation of Primary Hyperparathyroidism

Nakasone, Yasuto and Uchino, Shinya and Sato, Yuka and Yamauchi, Keishi and Aizawa, Toru (2015) Seizure and Profound Hypokalemia: Unusual Presentation of Primary Hyperparathyroidism. European Journal of Case Reports in Internal Medicine, 2 (3). pp. 1-3. ISSN 2284-2594

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A 68-year-old man was admitted because of tonic–clonic convulsion. He had been receiving 200 mg itraconazole for 10 days. He had hypokalaemia (2.2 mEq/l), hypercalcaemia (Cacorr 11.0 mg/dl) and elevated serum parathyroid hormone (PTH, 95 pg/ml). Ultrasound examination of the neck revealed a low echoic tumour. Cessation of itraconazole and fluid supplementation eradicated clinical symptoms and profound hypokalaemia, but serum potassium remained low normal (3.4 mEq/l) and the mild hypercalcaemia and elevated PTH were unchanged. To conclude, a small amount of itraconazole (200 mg) precipitated profound hypokalaemia and seizure in a patient with mild hyperparathyroidism and low normal serum potassium.

Item Type: Article
Uncontrolled Keywords: Seizure, hypokalaemia, hyperparathyroidism, itraconazole
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.4 Malattie del sistema emopoietico, linfatico, ghiandolare; Malattie del sistema endocrino
Depositing User: Chiara D'Arpa
Date Deposited: 13 Sep 2016 16:20
Last Modified: 13 Sep 2016 16:20

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