Garin, Nicolas and Arnold, Pierre (2015) Life-Threatening Adverse Reaction after Self-Initiated, Off-Label Use of High Dose Nicotinamide for the Treatment of Friedreich’s Ataxia. European Journal of Case Reports in Internal Medicine, 2 (3). pp. 1-3. ISSN 2284-2594
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Abstract
A 40-year old woman, previously known for Friedreich’s ataxia, presented with shock, profound lactic acidosis and hepatic failure after ingestion of a high dose of nicotinamide, the amide form of vitamin B3. On her own initiative, she was taking up to 4.4 g per day of nicotinamide, after having learned the results of a phase 2 study suggesting a potential benefit in Friedreich’s ataxia. The outcome was good with supportive care and withdrawal of nicotinamide.
| Item Type: | Article |
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| Uncontrolled Keywords: | niacin, nicotinic acid, nicotinamide, vitamin B3, Friedreich’s ataxia, toxicity, intoxication, adverse effect |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Chiara D'Arpa |
| Date Deposited: | 13 Sep 2016 16:23 |
| Last Modified: | 13 Sep 2016 16:23 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/15022 |
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