Hydroxychloroquine Myocardial Toxicity in a Patient with Systemic Lupus Erythematosus

Malchair, Pierre and Labori, Maria and Rubio-Rivas, Manuel and Salazar-Mendiguchia, Joel and Baixeras, Nuria and Corbella, Xavier (2015) Hydroxychloroquine Myocardial Toxicity in a Patient with Systemic Lupus Erythematosus. European Journal of Case Reports in Internal Medicine, 2 (3). pp. 1-3. ISSN 2284-2594

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Hydroxychloroquine is an antimalarial drug used in many rheumatologic and systemic diseases. Although considered by clinicians to be relatively safe, serious side effects have been documented (retinotoxicity, neuromyotoxicity and cardiotoxicity). We present the case of a 41-year-old woman with systemic lupus erythematosus (SLE) who presented at our institution with acute heart failure after taking hydroxychloroquine for a period of 3 months. An endomyocardial biopsy ruled out myocarditis related to systemic lupus erythematosus but demonstrated pathological changes related to hydroxychloroquine toxicity. It is exceptional to observe such cardiac toxicity after such a low cumulative dose (16 grams). The potential severity and reversibility of this complication underscores the importance of a high level of suspicion and timely diagnosis.

Item Type: Article
Uncontrolled Keywords: Hydorxychloroquine, cardiotoxicity, heart failure, side effect, systemic lupus erythematosus
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 13 Sep 2016 16:27
Last Modified: 13 Sep 2016 16:27
URI: http://eprints.bice.rm.cnr.it/id/eprint/15025

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