Hepcidin and Ferritin Levels in Fever of Unknown Origin: Is There a New Biomarker?

Lopez Aparicio, Ana and García-Espona-Pancorbo, Alejandro and Clavero-Olmos, Marta and Muñoz-Roldán, Inmaculada and Del Castillo-Rueda, Alejandro (2015) Hepcidin and Ferritin Levels in Fever of Unknown Origin: Is There a New Biomarker? European Journal of Case Reports in Internal Medicine, 2 (6). pp. 1-3. ISSN 2284-2594

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Background and objectives: Significantly elevated serum ferritin levels are associated with both iron overload and some inflammatory conditions. Hepcidin is a protein that interferes with iron absorption in inflammatory states and acts as an acute-phase reactant. Materials and methods: Here we report the case a 33-year-old patient who presented with high fever, skin lesions and arthralgia lasting for 2 weeks. His ferritin level was 13,800 µg/l and his hepcidin level was 61 ng/dl. Results: The final diagnosis was adult onset Still's disease. The condition evolved satisfactorily with steroid treatment, but after several weeks the patient presented with an unexpected recurrence. Conclusions: Hepcidin is a good inflammatory marker that could be useful in the differential diagnosis of hyperferritinaemia.

Item Type: Article
Uncontrolled Keywords: Still disease; hyperferritinemia; hepcidin
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 14 Sep 2016 15:00
Last Modified: 14 Sep 2016 15:00
URI: http://eprints.bice.rm.cnr.it/id/eprint/15071

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