Mahieu, Rafael and Lavigne, Christian and Urbanski, Geoffrey and Fouchard Hubert, Isabelle and Ducancelle, Alexandra and Lunel-Fabiani, Françoise (2015) Successful Treatment Using Simeprevir, Sofosbuvir and Rituximab of a Severe Form of Hepatitis C Virus-related Mixed Cryoglobulinemia with Cardiac Involvement. European Journal of Case Reports in Internal Medicine, 2 (7). pp. 1-3. ISSN 2284-2594
|
Text
299-2276-1-PB.pdf - Published Version Download (164kB) | Preview |
Abstract
Numerous extrahepatic manifestations have been reported in hepatitis C virus (HCV) infection, particularly mixed cryoglobulinemia (MC). MC generally responds to clearance of HCV under pegylated-interferon plus ribavirin treatment. New direct-acting antiviral agents have been licensed for HCV under different combinations but have not been studied in severe forms of MC. Here, we present a case report describing a life-threatening form of MC with multivisceral involvement, which was successfully treated with concomitant rituximab, sofosbuvir and simeprevir. In light of the rapid clinical remission associated with sustained virological response and the excellent side-effect profile, this treatment should be considered as a first-line therapy in severe forms of MC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Mixed cryoglobulinemia; hepatitis C virus; sofosbuvir; simeprevir |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.9 Altre malattie (altri rami della Medicina) > 616.91 Malattie da virus |
| Depositing User: | Chiara D'Arpa |
| Date Deposited: | 14 Sep 2016 15:04 |
| Last Modified: | 14 Sep 2016 15:04 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/15075 |
Actions (login required)
 |
View Item |
