Anti-Signal Recognition Particle Myopathy in a Geriatric Patient

Ferreira, Diana Marques and Afonso Mendes, Patrícia and Aragão, António and Veríssimo, Manuel Teixeira and Carvalho, Armando (2015) Anti-Signal Recognition Particle Myopathy in a Geriatric Patient. European Journal of Case Reports in Internal Medicine, 2 (7). pp. 1-3. ISSN 2284-2594

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Anti-signal recognition particle (SRP) myopathy is a rare idiopathic inflammatory myositis that usually affects middle-age women, and is characterized by rapidly progressive proximal and symmetrical muscle weakness, elevated creatine kinase levels, severe necrotizing immune-mediated myopathy, presence of anti-SRP autoantibodies and poor response to steroid therapy. We report a geriatric case of a previously independent patient, presenting with slow onset of proximal paraparesis, myalgia and severe gait impairment. The patient was treated with steroid and azathioprine, with laboratory and pain response but modest muscle strength improvement. The clinical presentation of this unusual patient was atypical, which hampered the correct diagnosis.

Item Type: Article
Uncontrolled Keywords: Signal recognition particle; myositis; anti-SRP antibodies; idiopathic inflammatory myopathies
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 14 Sep 2016 15:04
Last Modified: 14 Sep 2016 15:04

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