Micallef, Daniel and Attard, Jason and Mallia Azzopardi, Charles and Boffa, Michael John (2016) Lymphadenopathy after Initiating HAART in an HIV-positive Patient with Kaposi's Sarcoma: a Case of Multicentric Castleman's Disease. European Journal of Case Reports in Internal Medicine, 2 (7). pp. 1-3. ISSN 2284-2594
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Abstract
We present the case of a 33-year-old lady who was diagnosed with disseminated Kaposi’s sarcoma and HIV infection. The patient improved on highly active antiretroviral therapy (HAART), however, nine days into treatment, she became febrile and dyspnoeic and developed tender cervical and axillary lymphadenopathy. Despite treatment for suspected sepsis and immune reconstitution, she died in intensive care. Lymph node biopsies revealed coexistent Castleman’s disease and Kaposi’s sarcoma. Initiation of HAART can be rarely associated with unmasking and rapid progression of Castleman’s disease, a phenomenon called immune reconstitution. Urgent investigation and treatment with agents such as steroids and cytotoxic drugs can be life-saving.
| Item Type: | Article |
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| Additional Information: | L'articolo è stato pubblicato nei Latest online nel 2015 |
| Uncontrolled Keywords: | Castleman's disease; Kaposi's sarcoma; immune reconstitution inflammatory syndrome |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Chiara D'Arpa |
| Date Deposited: | 14 Sep 2016 15:07 |
| Last Modified: | 14 Sep 2016 15:07 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/15093 |
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