Granulomatosis with Polyangiitis (Wegener Granulomatosis) Mimicking Infective Endocarditis

Rachdi, Imène and Baili, Lilia and Daoud, Fatma and Aydi, Zohra and Zoubeidi, Hana and Ben Dhaou, Basma and Boussema, Fatma (2014) Granulomatosis with Polyangiitis (Wegener Granulomatosis) Mimicking Infective Endocarditis. European Journal of Case Reports in Internal Medicine, 1 (1). pp. 1-5. ISSN 2284-2594

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Introduction Infective endocarditis (IE) has been reported to mimic granulomatosis with polyangiitis (GPA) and to test positive to antineutrophil cytoplasmic antibodies (ANCA), which may lead to a misdiagnosis and inappropriate treatment. Case presentation We report a case of a 59-year-old man admitted for purpura, gangrenous digital infarcts and glomerulonephritis. The diagnosis of IE was initially considered on the basis of heart murmur and two positive haemocultures to corynebacterium. Ineffectiveness of antimicrobial therapy and further neurological and nasal manifestations supported the diagnosis of GPA. Conclusions IE should be ruled out before initiation of immunosuppressive treatment. If the disease progresses despite antimicrobial treatment, vascular diseases should be rapidly taken into account in differential diagnosis and treated early to avoid fatal complications.

Item Type: Article
Uncontrolled Keywords: Granulomatosis with polyangiitis, endocarditis, haemocultures, antineutrophil cytoplasmic antibody (ANCA)
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 09 Sep 2016 12:59
Last Modified: 09 Sep 2016 12:59

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