Grima, Maria Angela and Camilleri, David James (2016) A Case of Internal Carotid Artery Thrombosis associated with Thalidomide Administration in Multiple Myeloma. European Journal of Case Reports in Internal Medicine, 3 (4). pp. 1-3. ISSN 2284-2594
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Abstract
Thalidomide is an effective chemotherapeutic agent used to achieve remission in multiple myeloma. However, its administration is associated with several adverse effects including venous thromboembolism, while arterial thrombosis has also, although rarely, been described in the literature. We report a case of internal carotid artery occlusion within 1 week of starting thalidomide with prophylactic low molecular weight heparin in a patient who had no other prothrombotic risk factors. It is not known why this complication occurs despite the administration of anticoagulant prophylaxis. The role of factor VIII, von Willebrand factor antigen levels and fibrinogen in multiple myeloma patients should be studied in order to determine if these factors should be targeted in future prophylactic treatment.
| Item Type: | Article |
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| Uncontrolled Keywords: | Multiple myeloma; thalidomide; arterial thrombosis; cerebrovascular accident |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Chiara D'Arpa |
| Date Deposited: | 27 Sep 2016 10:28 |
| Last Modified: | 27 Sep 2016 10:28 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/15153 |
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