Kalafateli, Maria and Triantos, Christos and Tsamandas, Athanasios and Dalekos, George N. (2016) Spontaneous Cirrhosis Regression in an IFN-beta-induced AIH-like Syndrome Following Drug Withdrawal: Art of Facts or Artifacts? European Journal of Case Reports in Internal Medicine, 3 (4). pp. 1-4. ISSN 2284-2594
|
Text
396-2754-1-PB.pdf - Published Version Download (553kB) | Preview |
Abstract
Autoimmune hepatitis (AIH) is a disease of unknown aetiology with drug-induced AIH being the most complex and not fully understood type. We present the case of a 57-year-old female patient with acute icteric hepatitis after interferon-beta-1b (IFNβ-1b) administration for multiple sclerosis (MS). Based on liver autoimmune serology, histology and appropriate exclusion of other liver diseases, a diagnosis of AIH-related cirrhosis was established. Following discontinuation of IFNβ-1b, a complete resolution of biochemical activity indices was observed and the patient remained untreated on her own decision. However, 3 years later, after a course of intravenous methylprednisolone for MS, a new acute transaminase flare was recorded which subsided again spontaneously after 3 weeks. Liver biopsy and elastography showed significant fibrosis regression (F2 fibrosis). To our knowledge, this is the first report showing spontaneous cirrhosis regression in an IFNβ-1b-induced AIH-like syndrome following drug withdrawal, suggesting that cirrhosis might be reversible if the offending fibrogenic stimulus is withdrawn.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Autoimmune hepatitis; cirrhosis; drug-induced liver injury; interferon-beta; multiple sclerosis |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Chiara D'Arpa |
| Date Deposited: | 27 Sep 2016 10:31 |
| Last Modified: | 27 Sep 2016 10:31 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/15161 |
Actions (login required)
 |
View Item |
