The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons

Romano, Adele and Cassano, Tommaso and Tempesta, Bianca and Cianci, Silvia and Dipasquale, Pasqua and Coccurello, Roberto and Cuomo, Vincenzo and Gaetani, Silvana (2013) The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons. Peptides, 49. pp. 21-26. ISSN 0196-9781

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The anandamide monounsaturated analogue oleoylethanolamide (OEA) acts as satiety signal released from enterocytes upon the ingestion of dietary fats to prolong the interval to the next meal. This effect, which requires intact vagal fibers and intestinal PPAR-alpha receptors, is coupled to the increase of c-fos and oxytocin mRNA expression in neurons of the paraventricular nucleus (PVN) and is prevented by the intracerebroventricular administration of a selective oxytocin antagonist, thus suggesting a necessary role of oxytocinergic neurotransmission in the pro-satiety effect of OEA. By brain microdialysis and immunohistochemistry, in this study we demonstrate that OEA treatment can stimulate oxytocin neurosecretion from the PVN and enhance oxytocin expression at both axonal and somatodendritic levels of hypothalamic neurons. Such effects, which are maximum 2h after OEA administration, support the hypothesis that the satiety-inducing action of OEA is mediated by the activation of oxytocin hypothalamic neurons.

Item Type: Article
Uncontrolled Keywords: animal experiment; article; blood brain barrier; gastrointestinal tract; hypothalamus; immunohistochemistry; immunoreactivity; male; microdialysis; nerve cell; neurohypophysis; neurosecretion; neurotransmission; nonhuman; oncogene c fos; optical density; priority journal; rat; satiety
Subjects: 500 Scienze naturali e Matematica
500 Scienze naturali e Matematica > 570 Scienze della vita; Biologia
Depositing User: PhD Roberto Coccurello
Date Deposited: 19 Dec 2016 14:21
Last Modified: 19 Dec 2016 14:21

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