Ventura, R. and Coccurello, R. and Andolina, D. and Latagliata, E. C. and Zanettini, C. and Lampis, V. and Battaglia, M. and D'Amato, F. R. and Moles, A. (2013) Postnatal Aversive Experience Impairs Sensitivity to Natural Rewards and Increases Susceptibility to Negative Events in Adult Life. Cerebral Cortex, 23 (7). pp. 1606-1617. ISSN 1047-3211
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Abstract
Evidence shows that maternal care and postnatal traumatic events can exert powerful effects on brain circuitry development but little is known about the impact of early postnatal experiences on processing of rewarding and aversive stimuli related to the medial prefrontal cortex (mpFC) function in adult life. In this study, the unstable maternal environment induced by repeated cross-fostering (RCF) impaired palatable food conditioned place preference and disrupted the natural preference for sweetened fluids in the saccharin preference test. By contrast, RCF increased sensitivity to conditioned place aversion (CPA) and enhanced immobility in the forced swimming test. Intracerebral microdialysis data showed that the RCF prevents mpFC dopamine (DA) outflow regardless of exposure to rewarding or aversive stimuli, whereas it induces a strong and sustained prefrontal norepinephrine (NE) release in response to different aversive experiences. Moreover, the selective mpFC NE depletion abolished CPA, thus indicating that prefrontal NE is required for motivational salience attribution to aversionrelated stimuli. These findings demonstrate that an unstable maternal environment impairs the natural propensity to seek pleasurable sources of reward, enhances sensitivity to negative events in adult life, blunts prefrontal DA outflow, and modulates NE release in the reverse manner depending on the exposure to rewarding or aversive stimuli.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cross-fostering, dopamine, norepinephrine, prefrontal cortex, salience attribution |
| Subjects: | 500 Scienze naturali e Matematica 500 Scienze naturali e Matematica > 570 Scienze della vita; Biologia |
| Depositing User: | PhD Roberto Coccurello |
| Date Deposited: | 19 Dec 2016 13:48 |
| Last Modified: | 19 Dec 2016 13:48 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/15477 |
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