A Murine Model of Atypical Antipsychotic-Induced Weight Gain and Metabolic Dysregulation

Coccurello, Roberto and Moles, Anna (2010) A Murine Model of Atypical Antipsychotic-Induced Weight Gain and Metabolic Dysregulation. Current protocols in neuroscience. Supplements, 52. 9.33.1-9.33.22. ISSN 1934-8576

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Abstract

In comparison with conventional, first-generation antipsychotics (e.g., haloperidol), the administration of atypical antipsychotics (AAPs) has been associated with a higher risk of metabolic derangements, including body weight increase, dysregulation of glucose homeostasis, fat accumulation, and even liability to develop type II diabetes. Since this is a serious clinical problem that may be further exacerbated in overweight schizophrenics, establishing animal models of AAP-induced adverse effects may contribute to clarifying the mechanisms underlying these effects. Here we present three basic protocols by which this problem has been modeled. The three protocols differ in many aspects (routes of administration, extent of the chronic treatment, diets, and dosage regimen), and the pros and cons of each procedure are systematically detailed throughout. It should be noted that several factors (e.g., species, sex, duration, and class of AAPs) could restrict the feasibility of these models, as well as their correspondence to the clinical condition

Item Type:	Article
Uncontrolled Keywords:	atypical antipsychotic, olanzapine, weight gain, metabolic dysregulation, food intake, high-fat diet
Subjects:	500 Scienze naturali e Matematica 500 Scienze naturali e Matematica > 570 Scienze della vita; Biologia
Depositing User:	PhD Roberto Coccurello
Date Deposited:	19 Dec 2016 13:55
Last Modified:	19 Dec 2016 13:55
URI:	http://eprints.bice.rm.cnr.it/id/eprint/15485

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