Grasso, Giuseppe and Mielczarek, Przemyslaw and Niedziolka, Magdalena and Silberring, Jerzy (2014) Metabolism of Cryptic Peptides Derived from Neuropeptide FF Precursors: The Involvement of Insulin-Degrading Enzyme. International Journal of Molecular Sciences, 15. pp. 16787-16799. ISSN 1422-0067
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Abstract
The term “cryptome” refers to the subset of cryptic peptides with bioactivities that are often unpredictable and very different from the parent protein. These cryptic peptides are generated by proteolytic cleavage of proteases, whose identification in vivo can be very challenging. In this work, we show that insulin-degrading enzyme (IDE) is able to degrade specific amino acid sequences present in the neuropeptide pro-NPFFA (NPFF precursor), generating some cryptic peptides that are also observed after incubation with rat brain cortex homogenate. The reported experimental findings support the increasingly accredited hypothesis, according to which, due to its wide substrate selectivity, IDE is involved in a wide variety of physiopathological processes.
| Item Type: | Article |
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| Subjects: | 500 Scienze naturali e Matematica > 540 Chimica e scienze connesse 500 Scienze naturali e Matematica > 570 Scienze della vita; Biologia > 572 Biochimica (Classificare qui la Citochimica, l'Istochimica, le opere d'insieme su Biochimica e Biofisica; le opere interdisciplinari sulle sostanze biochimiche, sulle macromolecole) |
| Depositing User: | Dr Giuseppe Grasso |
| Date Deposited: | 20 Dec 2016 13:54 |
| Last Modified: | 20 Dec 2016 13:54 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/15491 |
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