High level expression of the HMGI(Y) gene during embryonic development

Chiappetta, Gennaro and Avvantaggiato, Virginia and Visconti, Roberta and Fedele, Monica and Battista, Sabrina and Trapasso, Francesco and Merciai, Bianca Maria and Fidanza, Vincenzo and Giancotti, Vincenzo and Santoro, Massimo and Simeone, Antonio and Fusco, Alfredo (1996) High level expression of the HMGI(Y) gene during embryonic development. Oncogene, 13. pp. 2439-2446. ISSN 0950-9232

[img] Text
Chiappetta 1996.pdf - Published Version
Restricted to Repository staff only

Download (2MB)


The HMGI protein family includes three proteins, named HMG-I, HMG-Y and HMGI-C. The first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing mechanism. Their expression is elevated in neoplastic tissues and cells and this over-expression has a causal role in the process of cellular neoplastic transformation. We demonstrate that the HMGI(Y) gene is expressed at very low levels in normal adult tissues, whereas in embryonic tissues it is expressed at high levels comparable to those detected in neoplastic tissues. Specifically, a very high expression of the HMGI (Y) gene was detected in all embryonic tissues at 8.5 dpc. Then in the following days, even though the gene is expressed essentially in all tissues, an abundant gene expression was restricted to some tissues. These results indicate an important role of the HMGI (Y) gene in development.

Item Type: Article
Uncontrolled Keywords: Development, Embryo, HMGI proteins, in situ hybridization
Subjects: 500 Scienze naturali e Matematica
500 Scienze naturali e Matematica > 570 Scienze della vita; Biologia
Depositing User: Dr Roberta Visconti
Date Deposited: 11 Jan 2017 15:42
Last Modified: 11 Jan 2017 15:42
URI: http://eprints.bice.rm.cnr.it/id/eprint/15826

Actions (login required)

View Item View Item