Nasal Skin Necrosis: A Very Rare Manifestation of Antiphospholipid Syndrome

Ourique, Carolina Oliveira and Chora, Inês and Guimarães, Susana and Júlio, Sara and Vaz-Marques, Paula Nasal Skin Necrosis: A Very Rare Manifestation of Antiphospholipid Syndrome. European Journal of Case Reports in Internal Medicine, 4 (2). ISSN 2284-2594


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A 23-year-old woman, a smoker and oral oestrogen user, presented with nasal necrosis. No other symptoms or local trauma were described. Relevant laboratory findings included complement consumption, positive lupus-anticoagulant assay, increased rheumatoid factor and positive cryoglobulins. Screening for autoimmune conditions, haematological malignancies and infectious diseases was negative. Histological examination of the nasal skin showed small vessel occlusion without vasculitis. Later, a second positive lupus-anticoagulant assay supported the diagnosis of antiphospholipid syndrome. The patient improved with glucocorticoids and anticoagulation. This case report describes an unusual manifestation of antiphospholipid syndrome in a patient with cryoglobulinaemia contributing to the thrombotic event and highlights the importance of recognizing these overlapping disorders.

Item Type: Article
Uncontrolled Keywords: Cutaneous necrosis; antiphospholipid syndrome; cryoglobulinaemia
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Michela Donatelli
Date Deposited: 08 May 2017 13:11
Last Modified: 08 May 2017 13:11

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