Two Faces of the Same Coin: A Case Report of Antiphospholipid Syndrome Nephropathy

Homem de Melo Marques, Sofia and André Nascimento Ferreira, Hugo and Pires de Morais Nunes, Ana Teresa and Nicolau Pestana Silva, Roberto and Moreira Sampaio Norton, Susana Maria (2017) Two Faces of the Same Coin: A Case Report of Antiphospholipid Syndrome Nephropathy. European Journal of Case Reports in Internal Medicine, 4 (3). ISSN 2284-2594

542-3444-1-PB.pdf - Published Version

Download (342kB) | Preview
Official URL:


Antiphospholipid syndrome (APS) is an autoimmune disease which can be primary or secondary to other autoimmune conditions and is defined by the occurrence of arterial or venous thrombosis, or pregnancy morbidity associated with persistently positive antiphospholipid antibodies (aPLA). The kidney may be affected by thrombosis at any level of its vasculature. When small vessels are involved, this results in thrombotic microangiopathy (TMA), which can manifest as either acute vaso-occlusive or chronic vascular lesions in glomeruli, arterioles and interlobular arteries. We report the case of 26-year-old man, with a previous medical history suggestive of APS, who was found to have a small elevation in serum creatinine. A kidney biopsy was performed and revealed features of chronic TMA. Anticoagulation was begun and kidney function remained stable. However, one year later, upon suspension of anticoagulation, the patient developed acute kidney injury and a second kidney biopsy showed acute TMA. This case describes different manifestations of antiphospholipid syndrome nephropathy (APSN) and highlights the importance of anticoagulation for thrombosis prevention.

Item Type: Article
Uncontrolled Keywords: Antiphospholipid syndrome; antiphospholipid syndrome nephropathy; kidney biopsy; thrombotic microangiopathy
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Rebecca D'Amore
Date Deposited: 21 Sep 2017 12:58
Last Modified: 21 Sep 2017 12:58

Actions (login required)

View Item View Item