Late cellular effects of 12C ions

Grossi, G. and Bettega, D. and Calzolari, P. and Durante, M. and Elsässer, T. and Gialanella, G. and Hessel, P. and Manti, L. and Pugliese, M. and Ritter, S. and Santini, M. T. and Scampoli, P. and Weyrather, W. K. (2008) Late cellular effects of 12C ions. Il nuovo cimento C, 31 (1). pp. 39-47. ISSN 1826-9885

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The expanding role of particle-based radiation treatment of cancer (hadrontherapy) requires a thorough understanding of its possible late effects at the cellular and tissue levels. The biological effectiveness of a 12C ion beam in the induction of two biological endpoints, neoplastic transformation and premature cellular senescence was studied in human cells in vitro and compared to that exhibited by low linear energy transfer (LET) radiation. Cells were exposed to the therapeutic 12C ion beam used at GSI at various positions of the beam ionisation path, corresponding to the low-LET entrance channel (plateau), the high-LET Spread-Out Bragg Peak (SOBP) or at 3.8 cm past the SOBP. In the framework of the INFN-funded project ETIOPE, this paper reports preliminary results on survival and neoplastic transformation after a physical dose of 0.75 Gy, and on the onset of cellular senescence after 0.5 or 2 Gy of plateau- and SOBP-irradiated cells. A three-dimensional approach to investigate the effects 12C ion beams on the expression of cell adhesion molecules is also examined.

Item Type: Article
Uncontrolled Keywords: Effects of ionizing radiation on biological systems ; Therapeutic applications, including brachytherapy ; Cancer ; Tissue response
Subjects: 500 Scienze naturali e Matematica > 530 Fisica
Depositing User: Marina Spanti
Date Deposited: 23 Mar 2020 14:45
Last Modified: 23 Mar 2020 14:45

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