Cherubini, Roberto and De Nadal, V. and Gerardi, S. and Guryev, D. and Antoccia, A. and Berardinelli, F. and Sgura, A. and Tanzarella, C. (2008) Status report of a systematic investigation on low-dose ionizing radiation effects in mammalian cells. Il nuovo cimento C, 31 (1). pp. 57-67. ISSN 1826-9885
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Abstract
In the last 15 years a growing interest in the biological effects induced by low doses of ionizing radiation has arisen in the scientific community, due to an increasing number of experimental evidences showing a plethora of non-linear effects occurring after low-dose irradiations. In particular, hyper-radiosensitivity and induced radioresistance (HRS/IRR) have been reported after exposure to low- and high-LET radiation, in human (normal and tumoural) and other mammalian cells in vitro. In this framework, Chinese hamster V79 cells, human primary fibroblasts (HFFF2) and murine embryonic fibroblasts (MEFs) were irradiated with broadbeams of protons in the dose range 0.1–5.0Gy and at 1 Gy/min dose-rate. Cellular response has been evaluated in terms of cell survival, micronuclei induction, chromosomal aberrations and telomere length alterations. For comparison purpose, the same end-points were studied after X/γ-rays irradiation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Effects of ionizing radiation on biological systems ; Biophysical mechanisms of interaction ; Dosimetry/exposure assessment ; Cell-cell communication; collective behavior of motile cells |
| Subjects: | 500 Scienze naturali e Matematica > 530 Fisica |
| Depositing User: | Marina Spanti |
| Date Deposited: | 23 Mar 2020 14:47 |
| Last Modified: | 23 Mar 2020 14:47 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/16332 |
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