Goodpasture’s Syndrome with Negative Anti-glomerular Basement Membrane Antibodies

Berends-De Vries, Tjitske and Boerma, Susan and Doornabal, Joan and Dikkeschei, Bert and Stegeman, Coen and Veneman, Thiemo (2017) Goodpasture’s Syndrome with Negative Anti-glomerular Basement Membrane Antibodies. European Journal of Case Reports in Internal Medicine, 4 (8). ISSN 2284-2594

Godpasture.pdf - Published Version

Download (370kB) | Preview
Official URL:


A young male patient with rapidly progressive and life-threatening pulmonary haemorrhage due to anti-glomerular basement membrane (anti-GBM) antibody disease without renal involvement repeatedly tested negative for serum anti-GBM antibodies. Although rare, antiGBM antibody disease should be considered in the differential diagnosis in patients with life-threatening pulmonary haemorrhage due to isolated diffuse alveolar haemorrhage. Enzyme-linked-immunosorbent assay (ELISA) testing for anti-GBM antibodies in anti-GBM antibody disease can give false-negative results. A negative serum anti-GBM antibody test is therefore insufficient to exclude the diagnosis. Thus, a kidney or lung biopsy should be considered in any case with a high clinical suspicion but negative anti-GBM antibody test to confirm or rule out the diagnosis.

Item Type: Article
Uncontrolled Keywords: Goodpasture, diffuse alveolar hemorrhage, anti-GBM antibodies
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 26 Jan 2018 14:23
Last Modified: 26 Jan 2018 14:23

Actions (login required)

View Item View Item