ANCA-negative Granulomatosis with Polyangiitis: A Difficult Diagnosis

McCarthy, Eilis and Mustafa, Muneeb and Watts, Mike (2017) ANCA-negative Granulomatosis with Polyangiitis: A Difficult Diagnosis. European Journal of Case Reports in Internal Medicine, 4 (8). ISSN 2284-2594

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Granulomatosis with polyangitiis (GPA) is a systemic small and medium vessel vasculitis, commonly associated with anti-neutrophil cytoplasmic antibodies (ANCAs). Presenting signs and symptoms in GPA are varied and patients may present with constitutional, nonspecific symptoms, which can delay the diagnosis. Tissue biopsy of the site of active disease can confirm the diagnosis of GPA, in which necrotising granulomatous inflammation is seen. However, surrogate markers may be used for diagnosis without a tissue biopsy. They include upper and lower airway symptoms, signs of glomerulonephritis and a positive ANCA. However, approximately 10–20% of patients with GPA are ANCA negative, allowing for the diagnosis to be overlooked, particularly in those patients with non-specific findings. The reason for the absence of ANCAs is unclear.

Item Type: Article
Uncontrolled Keywords: Granulomatosis with polyangiitis
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 26 Jan 2018 14:20
Last Modified: 26 Jan 2018 14:20

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