Gastrointestinal Biopsy in Henoch-Schönlein Purpura: A Great Diagnostic Contribution

Akkari, Imen and Mrabet, Soumaya and Ben Jazia, Elhem (2017) Gastrointestinal Biopsy in Henoch-Schönlein Purpura: A Great Diagnostic Contribution. European Journal of Case Reports in Internal Medicine, 4 (9). ISSN 2284-2594

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Henoch-Schönlein purpura is an IgA-mediated immune vasculitis which is characterized by purpuric lesions and osteoarticular, intestinal and sometimes renal manifestations. The histopathological substrate of this entity is leucocytoclastic vasculitis (LCV) with IgA deposits seen on immunohistochemistry. We here report the case of a 27-year-old woman with abdominal pain and cutaneous purpura. Upper and lower endoscopic exploration showed purpuric lesions in the rectum but not in the stomach. Skin biopsy revealed LCV. IgA deposits were seen only in gastric mucosa. The patient was treated with corticoids which led to improvement of both the cutaneous and digestive symptoms. This case suggests that gastrointestinal biopsies of both normal and abnormal mucosa should be taken in Henoch-Schönlein purpura, especially in patients with atypical forms.

Item Type: Article
Uncontrolled Keywords: Henoch–Schönlein purpura, gastrointestinal disease, endoscopy
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 26 Jan 2018 10:10
Last Modified: 26 Jan 2018 10:10

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