Low-dose effects of ionizing radiations in in vitro and in vivo biological systems: A multi-scale approach study

Antoccia, A. and Argazzi, E. and Balata, M. and Bedogni, R. and Berardinelli, F. and Bisogni, G. and Bono, M. and Bottigli, U. and Brunetti, A. and Buttafava, A. and Castellani, G. and Centis, F. and Cesarini, W. and Cherubini, Roberto and Cossu, A. and Cugia, G. and Dattena, M. and De Nadal, V. and Dondi, D. and Esposito, A. and Faucitano, A. and Fiori, P. L. and Fusco, E. and Gerardi, S. and Laubenstein, M. and Lucarini, A. and Marengo, M. and Masala, G. L. and Nieri, D. and Nisi, S. and Picardi, F. and Pintus, G. and Posadino, A. and Randaccio, P. and Remondini, D. and Sgura, A. and Stramigioli, S. and Tanzarella, C. and Valentini, M. and Zamai, L. and Zini, G. and Zironi, I. (2011) Low-dose effects of ionizing radiations in in vitro and in vivo biological systems: A multi-scale approach study. Il nuovo cimento C, 34 (1). pp. 49-63. ISSN 1826-9885

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Long-term biological effects of low-dose radiation are little known nowadays and its carcinogenic risk is estimated on the assumption that the risk remains linearly proportional to the radiation dose down to low-dose levels. However in the last 20 years this hypothesis has gradually begun to seem in contrast with a huge collection of experimental evidences, which has shown the presence of a plethora of non-linear phenomena (including hypersensitivity and induced radioresistance, adaptive response, and non-targeted phenomena like bystander effect and genomic instability) occurring after low-dose irradiation. These phenomena might imply a non-linear behaviour of cancer risk curves in the low-dose region and question the validity of the Linear No-Threshold (LNT) model currently used for cancer risk assessment through extrapolation from existing high-dose data. Moreover only few information is available regarding the effects induced on cryopreserved cells by multi-year background radiation exposure, which might induce a radiation-damage accumulation, due to the inhibition of cellular repair mechanisms. In this framework, the multi-year EXCALIBUR (EXposure effeCts At Low doses of Ionizing radiation in Biological CultURes) experiment, funded by INFN-CNS5, has undertaken a multiscale approach investigation on the biological effects induced in in vitro and in vivo biological systems, in culture and cryopreserved conditions, as a function of radiation quality (X/γ-rays, protons, He-4 ions of various energies) and dose, with particular emphasis on the low-dose region and non-linear phenomena, in terms of different biological endpoints.

Item Type: Article
Uncontrolled Keywords: Effects of ionizing radiation on biological systems ; Biophysical mechanisms of interaction ; Dosimetry/exposure assessment ; Cell-cell communication; collective behavior of motile cells
Subjects: 500 Scienze naturali e Matematica > 530 Fisica
Depositing User: Marina Spanti
Date Deposited: 03 Apr 2020 15:11
Last Modified: 03 Apr 2020 15:11
URI: http://eprints.bice.rm.cnr.it/id/eprint/17180

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