Esposito, M. and Bosco, P. and Rei, L. and Aiello, M. (2011) Volumetric analysis on MRI and PET images for the early diagnosis of Alzheimer’s disease. Il nuovo cimento C, 34 (1). pp. 175-185. ISSN 1826-9885
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Abstract
In this paper we present the development of a software for the extraction of the hippocampus and surrounding medial-temporal-lobe (MTL) regions from T1-weighted magnetic resonance (MR) and from Positron Emission Tomography (PET) images with no interactive input from the user. With this software we introduce a novel statistical index computed on the intensities in the automatically extracted MTL regions. This index is a measure of gray-matter (GM) atrophy and allows to: distinguish between (a) patients with Alzheimer’s disease (AD), patients with amnestic mild cognitive impairment (aMCI), (b) patients with amnestic mild cognitive impairment who will later develop AD in a time frame of 2 years (aMCIconv), and (c) a set of age-matched elderly controls. Once refined, this method could be used to infer about the clinical outcome of aMCI patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Registration ; Segmentation ; Computer-aided diagnosis ; Clinical applications |
| Subjects: | 500 Scienze naturali e Matematica > 530 Fisica |
| Depositing User: | Marina Spanti |
| Date Deposited: | 03 Apr 2020 15:22 |
| Last Modified: | 03 Apr 2020 15:22 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/17195 |
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