Severe Intestinal Bleeding in a Woman with Glanzmann Thrombasthenia

Mesquita, Raquel and Santos, Inês and Monteiro, Helena (2017) Severe Intestinal Bleeding in a Woman with Glanzmann Thrombasthenia. European Journal of Case Reports in Internal Medicine, 5 (2). ISSN 2284-2594

document (13).pdf - Published Version

Download (234kB) | Preview
Official URL:


Glanzmann thrombasthenia (GT) is a rare inherited disorder associated with abnormal platelet function. Non-surgical bleeding is common and can be life-threatening. A 70-year-old woman with GT presented with a 3 week history of melena and asthenia. She had hemoglobin of 3.8 g/dL. Both upper and lower endoscopies were inconclusive. Video capsule endoscopy showed multiple angioectasias and erosions in the distal ileum. Following several days of recurring intestinal hemorrhage, only treatment with recombinant activated factor VII proved to be effective, enabling patient stabilization with no further bleeding. Control and prevention of bleeding among these patients is imperative and remains challenging.

Item Type: Article
Uncontrolled Keywords: Glanzmann thrombasthenia, bleeding, rFVIIa
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 18 May 2018 14:25
Last Modified: 18 May 2018 14:25

Actions (login required)

View Item View Item