Vesza, Zsófia and Pires, Catarina and Marques da Silva, Pedro (2018) Statin-related Lichenoid Dermatosis: An Uncommon Adverse Reaction to a Common Treatment. European Journal of Case Reports in Internal Medicine, 5 (5). ISSN 2284-2594
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Abstract
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are generally safe and well-tolerated drugs that are extensively used for the primary and secondary prevention of atherosclerotic cardiovascular events. Muscle and liver adverse reactions are the best recognized, while cutaneous side effects are exceedingly rare. We present the case of a 65-year-old woman with severe hypercholesterolemia, who developed generalized erythematous cutaneous lesions with pruritus, resembling lichen planus, months after starting treatment with simvastatin. The symptoms disappeared on withdrawal of simvastatin and reappeared within 3 months upon rechallenge with rosuvastatin. In addition to describing a rare adverse effect of statins, the authors also discuss the nutraceutical approach to the management of a statin-intolerant patient.
| Item Type: | Article |
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| Uncontrolled Keywords: | Lichenoid drug eruption, dyslipidemia, statins, nutraceuticals, red yeast rice |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Chiara D'Arpa |
| Date Deposited: | 06 Aug 2018 09:47 |
| Last Modified: | 06 Aug 2018 09:47 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/18149 |
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